Inefficient A-to-I RNA editing and ALS
نویسندگان
چکیده
منابع مشابه
[Inefficient A-to-I RNA editing and ALS].
GluR2 is a subunit of the AMPA receptor, and failure of naturally occurring adenosine to inosine (A-to-I) conversion at its Q R site results in an increase of Ca influx through the AMPA receptor, thereby inducing exaggerated neuronal excitation. Indeed, mutant mice unable to edit this site die from status epilepticus. A-to-I conversion at this site is inefficient in the dying motor neurons of s...
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ژورنال
عنوان ژورنال: Rinsho Shinkeigaku
سال: 2010
ISSN: 0009-918X,1882-0654
DOI: 10.5692/clinicalneurol.50.978